This year, the Signature Series delves into the transformative power of Artificial Intelligence (AI) in both health care and health policy. In an era where data-driven decisions are paramount, AI offers unprecedented opportunities for efficiency, personalization, and innovation on a mass scale. Yet, it also raises critical questions about ethics, privacy, and equitable access. Our Series brings together the sharpest minds in the field to dissect these complexities. Through our unique model of diverse dialogue and evidence-based discourse, we will explore how AI can and is reshaping health care and health policy.